Which side effect is NOT associated with ARBs?

Which side effect is NOT associated with ARBs?

• A. Cough
• B. Headache
• C. Diarrhea
• D. Fatigue

Answer: (A)

Angiotensin II receptor blockers (ARBs) are primarily used to manage conditions like hypertension and heart failure. They are favored for their side effect profile compared to other medications, such as ACE inhibitors. One of the hallmark side effects of ACE inhibitors is a persistent dry cough, due to the accumulation of bradykinin. Conversely, ARBs do not lead to increased levels of bradykinin in the same way, which is why a cough is not typically associated with their use. The other side effects, such as headache, diarrhea, and fatigue, are observed with ARBs. Headaches can result from changes in blood pressure, diarrhea may occur as the gastrointestinal system adjusts to the medication, and fatigue could stem from the overall effects of lowering blood pressure or fluid management. Therefore, the absence of cough as a side effect makes it distinct from the other options, affirming its selection as the correct answer.

Angiotensin II receptor blockers (ARBs) are primarily used to manage conditions like hypertension and heart failure. They are favored for their side effect profile compared to other medications, such as ACE inhibitors. One of the hallmark side effects of ACE inhibitors is a persistent dry cough, due to the accumulation of bradykinin. Conversely, ARBs do not lead to increased levels of bradykinin in the same way, which is why a cough is not typically associated with their use.

The other side effects, such as headache, diarrhea, and fatigue, are observed with ARBs. Headaches can result from changes in blood pressure, diarrhea may occur as the gastrointestinal system adjusts to the medication, and fatigue could stem from the overall effects of lowering blood pressure or fluid management.

Therefore, the absence of cough as a side effect makes it distinct from the other options, affirming its selection as the correct answer.