What is a key genetic marker for hypersensitivity to Carbamazepine?

What is a key genetic marker for hypersensitivity to Carbamazepine?

• A. HLAB 1501
• B. HLAB 1502
• C. HLAB 1503
• D. HLAB 1504

Answer: (B)

The key genetic marker for hypersensitivity to Carbamazepine is HLAB 1502. This marker is particularly associated with an increased risk of severe cutaneous adverse reactions in individuals, especially in certain populations, such as those of Asian descent. The presence of this allele indicates a genetic predisposition, helping healthcare providers identify patients who may be at higher risk for these serious side effects when prescribed Carbamazepine. Knowing this marker is crucial for personalized medicine, where treatment decisions can be tailored based on a patient's genetic makeup to minimize the risk of adverse reactions.

The key genetic marker for hypersensitivity to Carbamazepine is HLAB 1502. This marker is particularly associated with an increased risk of severe cutaneous adverse reactions in individuals, especially in certain populations, such as those of Asian descent. The presence of this allele indicates a genetic predisposition, helping healthcare providers identify patients who may be at higher risk for these serious side effects when prescribed Carbamazepine. Knowing this marker is crucial for personalized medicine, where treatment decisions can be tailored based on a patient's genetic makeup to minimize the risk of adverse reactions.